[Heart-lung transplantation and cystic fibrosis. Indications and results].

Abstract

BACKGROUND:

Heart lung transplantation for++ cystic fibrosis is now performed in patients with severe lung disease but the experience is still scarce with the exception of some specialized centers.

PATIENTS AND METHODS:

Twenty-one patients underwent heart-lung transplantation between September 1989 and November 1994 in our institution, with a high standard of reliability in tracheal anastomosis and with a low incidence of hospital mortality (5%).

RESULTS:

The actuarial patient survival is 90.2% (95% confidence interval, 70 to 97%) at 1 year and 75.7% (95% confidence interval, 51 to 90%) at 3 and 4 years. The mean forced expiratory volume in 1 second (FEV1) increases from 20.1% predicted preoperatively to 76.1%.

CONCLUSION:

Despite the presence of airway pathogens, these results confirm that heart-lung transplantation for cystic fibrosis leads to a pronounced improvement in lung function and good rehabilitation after surgery. The two main obstacles are the shortage of donor organs and the possibility of late deterioration in lung function with a progressive airflow obstruction.

• Authors: A Haloun, P Despins, D Horeau, M Threilhaud, D Portier, A Y De Lajartre, B Jegou, O Al Habach, M Train, D Duveau, J Caillon, J L Michaud
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 3 Issue 5 Pg. 427-32 (May 1996) ISSN: 0929-693X [Print] France
• Vernacular Title: Transplantation cardiopulmonaire et mucoviscidose. Indications et résultats.
• PMID: 8763711 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Child
• Cystic Fibrosis (surgery)
• Female
• Forced Expiratory Volume
• Heart-Lung Transplantation (methods, statistics & numerical data)
• Humans
• Male
• Morbidity
• Postoperative Period