Abstract |
We investigated the short-term effects of an intrathecal bolus injection of baclofen on central pain due to stroke or spinal cord injury. Pain relief was obtained in 64% of the patients. The effects developed 1-2 hours after the injection and continued for 10-24 hours. Both spinal segmental and supraspinal mechanisms may be involved in the production of baclofen- analgesia.
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Authors | T Taira, H Kawamura, T Tanikawa, H Kawabatake, H Iseki, A Ueda, K Takakura |
Journal | Acta neurochirurgica. Supplement
(Acta Neurochir Suppl)
Vol. 64
Pg. 136-8
( 1995)
ISSN: 0065-1419 [Print] Austria |
PMID | 8748602
(Publication Type: Journal Article)
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Chemical References |
- Muscle Relaxants, Central
- Baclofen
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Topics |
- Afferent Pathways
(drug effects)
- Aged
- Baclofen
(administration & dosage, adverse effects)
- Cerebrovascular Disorders
(complications)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Humans
- Injections, Spinal
- Male
- Middle Aged
- Muscle Relaxants, Central
(administration & dosage, adverse effects)
- Pain
(drug therapy)
- Spinal Cord Injuries
(complications)
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