Abstract |
Renal disease in Primary Sjögren's syndrome (SS) is often overlooked, because of a paucity of symptoms. Distal renal tubular acidosis ( dRTA) and tubulointerstitial nephritis ( TIN) might be present. Only a few cases of SS with decreased glomerular filtration rate (GFR) have been reported. We have studied GFR in 27 female SS-patients, mean age 62 years (37-78). GFR was measured as the single injection 51Cr-EDTA plasma clearance. Eighteen women had normal GFR (group 1), and nine (33%) had values below the lower normal limit (group 2). In group 2, dRTA was present in 8/9 urolithiasis in 6/9, previous upper urinary tract infection (UTI) in 2/9 and TIN in 5/6 patients who were kidney biopsied. Among patients with dRTA 8/18 (44%) had decreased GFR. We conclude that decreased GFR is not unusual in SS-patients with dRTA, and decreased GFR is mostly associated with TIN. Urolithiasis and UTI may contribute to decreased GFR in some individuals.
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Authors | P Eriksson, T Denneberg, G Granerus, F Lindström |
Journal | Scandinavian journal of urology and nephrology
(Scand J Urol Nephrol)
Vol. 30
Issue 2
Pg. 121-7
(Apr 1996)
ISSN: 0036-5599 [Print] England |
PMID | 8738057
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Acidosis, Renal Tubular
(diagnosis, physiopathology)
- Adult
- Aged
- Female
- Glomerular Filtration Rate
(physiology)
- Humans
- Kidney Calculi
(diagnosis, physiopathology)
- Kidney Function Tests
- Middle Aged
- Nephritis, Interstitial
(diagnosis, physiopathology)
- Reference Values
- Sjogren's Syndrome
(diagnosis, physiopathology)
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