[The comparative clinico-experimental characteristics of aminostigmine and galanthamine used for treating poisonings by choline-blocking substances].

Abstract

The results of application of cholinesterase inhibitors, aminostigmin and galantamin, for treatment of acute poisoning with cyclodol, dimedrol, and solutan of moderately grave condition are presented. Aminostigmin was shown to exhibit the more pronounced stable and universal effect. The experiments in animals showed that aminostigmine affected peripheral and central M-cholinoreactive structures and conjugated with them more actively than galantamin. Aminostigmin, but not galantamin increases the rate of dopamine circulation and content of cyclic guanozinemonophosphate in frontal brain of rats, and this effect is exhibited even under the conditions of N-cholinoreceptor blockade with amizyl.

• Authors: V B Prozorovskiĭ, V D Velikova, N N Pshenkina, E T Vasilenko
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1996 Jan-Feb Vol. 59 Issue 1 Pg. 64-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia kliniko-éksperimental'naia kharakteristika aminostigmina i galantamina, ispol'zuemykh dlia lecheniia otravleniĭ kholinoblokiruiushchimi veshchestvami.
• PMID: 8704639 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidotes
• Carbamates
• Cholinergic Antagonists
• Cholinesterase Inhibitors
• Pyridines
• Receptors, Cholinergic
• Receptors, Dopamine
• Galantamine
• aminostigmine
• Pyridostigmine Bromide

Topics

• Acute Disease
• Animals
• Antidotes (pharmacology, therapeutic use)
• Brain (drug effects, metabolism)
• Brain Chemistry (drug effects)
• Carbamates
• Cholinergic Antagonists (poisoning)
• Cholinesterase Inhibitors (pharmacology, therapeutic use)
• Drug Evaluation
• Drug Evaluation, Preclinical
• Galantamine (pharmacology, therapeutic use)
• Humans
• Mice
• Poisoning (drug therapy)
• Pyridines
• Pyridostigmine Bromide (analogs & derivatives)
• Rats
• Receptors, Cholinergic (drug effects, metabolism)
• Receptors, Dopamine (drug effects, metabolism)