Abstract | PURPOSE: To determine whether radiographically proved calcifications in core biopsy specimens are better preserved in a nonaqueous fixative than in aqueous solutions. MATERIALS AND METHODS: One hundred fifty core biopsy specimens were taken from two female breast specimens that had been preserved in ethanol. Forty-one of the specimens with radiographically proved microcalcifications were divided into four groups and deposited in four different solutions: 10% formaldehyde, 0.9% sodium chloride, electrolyte solution, and 74.1% ethanol with 10% 2-propanol. The core specimens were radiographed again after 1 and 3 days. Five ethanol-preserved specimens were also reexamined radiographically after 2 weeks. RESULTS: Within 3 days, total radiographic disappearance of microcalcifications was observed in all core biopsy specimens that were immersed in solutions with high water content. In those core specimens preserved in ethanol, microcalcifications showed no change. CONCLUSION:
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Authors | J D Moritz, S Luftner-Nagel, J P Westerhof, J W Oestmann, E Grabbe |
Journal | Radiology
(Radiology)
Vol. 200
Issue 2
Pg. 361-3
(Aug 1996)
ISSN: 0033-8419 [Print] United States |
PMID | 8685326
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Electrolytes
- Water
- Formaldehyde
- Ethanol
- Sodium Chloride
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Topics |
- Biopsy
- Breast
(pathology)
- Breast Neoplasms
(diagnostic imaging, pathology)
- Calcinosis
(diagnostic imaging, pathology)
- Electrolytes
- Ethanol
- Female
- Formaldehyde
- Humans
- In Vitro Techniques
- Radiography
- Sodium Chloride
- Specimen Handling
- Time Factors
- Tissue Preservation
- Water
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