Abstract | BACKGROUND: A reduced local fibrinolysis seems to be an important mechanism in the formation of adhesions. Peritonitis may cause adhesions, and the aim of the present study was to determine peritoneal fibrinolytic capacity in inflamed and normal peritoneum. METHODS: RESULTS: t-PA exerted 95% of the PAA. PAA was significantly reduced (p < 0.01) during peritonitis (3.0 IU/micrograms protein; range, 0.3 to 4.2) compared with normal peritoneum (7.1 IU/micrograms protein; range, 0.6 to 18.1). A significant reduction (p < 0.05) in PAA occurred during operation both in normal peritoneum (3.8 IU/micrograms protein; range, 0.8 to 8.6) and in peritonitis (0.6 IU/micrograms protein; range, 0.16 to 2.1). Values are given as medians. CONCLUSIONS: The main PAA in human peritoneum was t-PA. The activity was decreasing during operation and reduced in peritonitis. This reduction in PAA might be a local response to inflammation.
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Authors | L Holmdahl, E Eriksson, M al-Jabreen, B Risberg |
Journal | Surgery
(Surgery)
Vol. 119
Issue 6
Pg. 701-5
(Jun 1996)
ISSN: 0039-6060 [Print] United States |
PMID | 8650612
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Plasminogen Activator Inhibitor 1
- Tissue Plasminogen Activator
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Topics |
- Abdomen
(surgery)
- Biopsy
- Fibrinolysis
- Humans
- Peritoneum
(metabolism)
- Peritonitis
(metabolism)
- Plasminogen Activator Inhibitor 1
(analysis)
- Tissue Plasminogen Activator
(analysis)
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