Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles.

Abstract

Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.

• Authors: E Allémann, J Rousseau, N Brasseur, S V Kudrevich, K Lewis, J E van Lier
• Journal: International journal of cancer (Int J Cancer) Vol. 66 Issue 6 Pg. 821-4 (Jun 11 1996) ISSN: 0020-7136 [Print] United States
• PMID: 8647656 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coloring Agents
• Drug Carriers
• Emulsions
• Indoles
• Lactates
• Organometallic Compounds
• Polyesters
• Polymers
• Radiation-Sensitizing Agents
• Suspensions
• hexadecafluoro zinc phthalocyanine
• Lactic Acid
• Polyethylene Glycols
• poly(lactide)
• cremophor EL
• Glycerol

Topics

• Animals
• Biodegradation, Environmental
• Coloring Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Drug Carriers
• Emulsions
• Glycerol (analogs & derivatives)
• Indoles (administration & dosage, pharmacokinetics, therapeutic use)
• Lactates
• Lactic Acid
• Male
• Mammary Neoplasms, Experimental (drug therapy, pathology)
• Mice
• Mice, Inbred BALB C
• Microspheres
• Neoplasm Transplantation
• Organometallic Compounds (administration & dosage, pharmacokinetics, therapeutic use)
• Particle Size
• Photochemotherapy
• Polyesters
• Polyethylene Glycols
• Polymers
• Radiation-Sensitizing Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Solubility
• Suspensions
• Thigh
• Tumor Cells, Cultured