Abstract | PURPOSE: METHODS: RESULTS: Intraocular pressure (IOP) was significantly (P<0.001) reduced and maintained by both medications without evidence of a long-term drift over 6 months. Comparing 6-month with baseline diurnal IOP values, the IOP reduction (mean +/- standard deviation) achieved with latanoprost (-6.7 +/- 3.4 mmHg) was significantly (P<0.001) greater than that produced with timolol (4.9 +/- 2.9 mmHg). Four patients treated with timolol and none treated with latanoprost were withdrawn from the study because of inadequate IOP control. Pulse rate was significantly reduced with timolol, but not with latanoprost. Slightly more conjunctival hyperemia appeared in latanoprost-treated compared with timolol-treated eyes. Fewer subjective side effects occurred in latanoprost-treated eyes. Both eyes of a patient with a characteristic, concentric iris heterochromia (darker centrally) at baseline showed a definite, photographically documented increase in pigmentation during latanoprost treatment, making the irides uniformly darker. Three additional patients treated with latanoprost were suspects for this color change. Otherwise, no significant difference between treatment groups occurred visual acuity, slit-lamp examination, blood pressure, and laboratory values. CONCLUSION:
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Authors | C B Camras |
Journal | Ophthalmology
(Ophthalmology)
Vol. 103
Issue 1
Pg. 138-47
(Jan 1996)
ISSN: 0161-6420 [Print] United States |
PMID | 8628544
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-Antagonists
- Ophthalmic Solutions
- Prostaglandins F, Synthetic
- Latanoprost
- Timolol
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Topics |
- Adrenergic beta-Antagonists
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Conjunctiva
(blood supply)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Glaucoma, Open-Angle
(drug therapy)
- Hemodynamics
(drug effects)
- Humans
- Hyperemia
(chemically induced)
- Intraocular Pressure
(drug effects)
- Iris Diseases
(chemically induced)
- Latanoprost
- Male
- Middle Aged
- Ocular Hypertension
(drug therapy)
- Ophthalmic Solutions
- Pigmentation Disorders
(chemically induced)
- Prostaglandins F, Synthetic
(administration & dosage, adverse effects, therapeutic use)
- Timolol
(administration & dosage, adverse effects, therapeutic use)
- United States
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