Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.

Abstract

The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.

• Authors: M Rocca, S Capelli, M Fini, M C Maltarello, F M Veronese, P Caliceti, R Giardino
• Journal: Bollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) 1995 May-Jun Vol. 71 Issue 5-6 Pg. 125-32 ISSN: 0037-8771 [Print] Italy
• PMID: 8519486 (Publication Type: Journal Article)

Chemical References

• Reactive Oxygen Species
• Polyethylene Glycols
• monomethoxypolyethylene glycol
• Superoxide Dismutase

Topics

• Animals
• Combined Modality Therapy
• Femoral Artery (surgery)
• Hindlimb (blood supply)
• Ischemia (drug therapy, surgery)
• Male
• Microscopy, Electron
• Microsurgery
• Polyethylene Glycols (administration & dosage)
• Rats
• Rats, Wistar
• Reactive Oxygen Species (metabolism)
• Reperfusion Injury (prevention & control)
• Superoxide Dismutase (administration & dosage, pharmacokinetics, therapeutic use)