[Treatment of polyneuropathy using sabeluzole].

Abstract

Two groups of patients suffering from polyneuropathy were treated by sabeluzol. The first group--a double blind placebo controlled study consisting of 30 diabetics of type II did not prove either significant differences of their subjective complaints or changes of their objective findings (the dose of sabeluzole being 2 x 10 mg/d). The second group--open study--consisting of 26 patients suffering from polyneuropathy of various origin, treated by sabeluzole 3 x 10 mg/d. The therapeutic effect was significantly higher in comparison to the above mentioned lower doses of the medicament (manifesting statistical significance of 5 and 10%); the authors make a point of sabeluzol's therapeutic efficacy, especially in cases with acute polyneuropathy onset and point out the necessity of several months lasting treatment. Positive effect upon the pseudoneurasthenic syndrome in many patients indicates its usefulness also in other disorders than are these of polyneuropathy.

• Authors: H Krejcová, D Vondrácková, Y Egerová, R Cerný
• Journal: Ceskoslovenska psychiatrie (Cesk Psychiatr) Vol. 89 Issue 1 Pg. 35-8 (Jan 1993) ISSN: 0069-2336 [Print] Czech Republic
• Vernacular Title: Lécba polyneuropatií sabeluzolem.
• PMID: 8508462 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Piperidines
• Thiazoles
• sabeluzole

Topics

• Diabetic Neuropathies (drug therapy)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Nervous System Diseases (drug therapy)
• Piperidines (therapeutic use)
• Thiazoles (therapeutic use)