Abstract |
Inflammation was induced in the lateral prostate of castrated Wistar rats by exposure to a sc implant of estradiol-filled Silastic tubing, followed by the addition of a dihydrotestosterone implant to restore prostatic wet weight. The presence of inflammation was correlated with increased serum PRL, elevated pituitary weight, and a greater than 2-fold increase in the lateral prostate DNA concentration. The administration of bromocriptine (4 mg/kg.day) to these animals was effective in suppressing pituitary weight and hyperprolactinemia and mitigated the lateral prostate inflammatory response. Inflammation was restored in the bromocriptine-treated hormone-implanted rats by administering exogenous ovine PRL at a dose of 2 mg/kg twice a day. The results indicate that estradiol-induced inflammation in the rat lateral prostate is mediated at least in part by the release of PRL from the pituitary.
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Authors | L Tangbanluekal, C L Robinette |
Journal | Endocrinology
(Endocrinology)
Vol. 132
Issue 6
Pg. 2407-16
(Jun 1993)
ISSN: 0013-7227 [Print] United States |
PMID | 8504745
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dihydrotestosterone
- Estradiol
- Prolactin
- DNA
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Topics |
- Animals
- DNA
(metabolism)
- Dihydrotestosterone
(metabolism)
- Estradiol
- Male
- Organ Size
- Osmolar Concentration
- Pituitary Gland
(pathology)
- Prolactin
(blood, physiology)
- Prostate
(metabolism)
- Prostatitis
(chemically induced, pathology)
- Rats
- Rats, Wistar
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