Ultrasonic diagnosis of 3,2'-dimethyl-4-aminobiphenyl induced tumors in the urogenital organs of F344 rats.

Abstract

The usefulness of transabdominal ultrasonography in the diagnosis of 3,2'-dimethyl-4-aminobiphenyl- and testosterone propionate-induced tumors of the urogenital organs was evaluated in F344 rats. Seven mass lesions (1 ventral prostate, 1 dorsolateral prostate, 3 seminal vesicles, and 1 kidney) in the urogenital organs could easily be diagnosed concerning size and localization by ultrasound. Histological examination revealed a lesion in the ventral prostate to be an abscess and the other tumors to be malignant. Three hydronephroses by tumor invasion to the ureter, and six tumors in organs other than the urogenital organs could be detected by ultrasound. The threshold of malignant tumor detection by ultrasound was 7 mm in actual length. The size of the mass lesion estimated by ultrasound correlated well with the direct measurement (r = 0.96). Transabdominal ultrasonography is useful for diagnosing the localization of experimental tumors and accurately measuring their size in the urogenital organs of rats.

• Authors: T Suzuki, Y Tamura, Y Takezawa, T Mashimo, K Imai, H Yuasa, H Yamanaka, T Shirai
• Journal: The Prostate (Prostate) Vol. 22 Issue 3 Pg. 235-41 ( 1993) ISSN: 0270-4137 [Print] United States
• PMID: 8488156 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminobiphenyl Compounds
• Carcinogens
• 2',3-dimethyl-4-aminobiphenyl
• Testosterone

Topics

• Adenocarcinoma (chemically induced, diagnostic imaging, pathology)
• Aminobiphenyl Compounds
• Animals
• Carcinogens
• Male
• Rats
• Rats, Inbred F344
• Testosterone
• Ultrasonography
• Urogenital Neoplasms (chemically induced, diagnostic imaging, pathology)