Growth of uremic infants on forced feeding regimens.

Abstract

Infants born with congenital renal insufficiency generally grow poorly during the first years of life and incur a height deficit that is rarely regained. Actual energy and protein requirements have not been determined for these children. In 12 infants with creatinine clearances less than 70 ml/min per 1.73 m2, growth and nutrient intakes were monitored during the first 2 years of life. Forced feeding regimens after 3 months of age, including gastrostomy in 3 patients, were necessary to maintain energy intakes near 100% of the recommended dietary allowance (RDA). Protein intakes averaged in excess of 140% RDA. Linear growth did not correlate with either energy or protein intakes, suggesting that neither was a limiting factor to growth. Length velocity standard deviation score (LV-SDS) did not correlate with degree of renal insufficiency at any age, but average LV-SDS did relate significantly and inversely to C-terminal parathyroid hormone (PTH) levels. Growth parameters, including LV-SDS and weight velocity SDS (WV-SDS) were lowest at 6 months of age. Weight and length SDS followed with a maximum decline at 12 months of age. While weight for length SDS remained normal and WV-SDS showed recovery during the 2nd year, LV-SDS remained negative. Length SDS stabilized near--2 SDS. In summary, these data suggest that the major height deficit in infants with renal insufficiency is incurred during the first 6 months of life. Ponderal indices suggested that very early nutritional deficits may have been a primary contributor to subsequent height deficits.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: C L Abitbol, G Zilleruelo, B Montane, J Strauss
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 7 Issue 2 Pg. 173-7 (Apr 1993) ISSN: 0931-041X [Print] Germany
• PMID: 8476713 (Publication Type: Journal Article)

Topics

• Enteral Nutrition
• Female
• Growth
• Humans
• Infant
• Infant Food
• Infant Nutritional Physiological Phenomena
• Male
• Nutritional Requirements
• Prospective Studies
• Renal Insufficiency (congenital)
• Uremia (congenital, physiopathology)