[Experimental studies on the development of residual stomach cancer--comparison of Billroth I and Billroth II].

Abstract

The effects of duodenogastric reflex on the development of residual stomach cancer and cell proliferation kinetics were investigated in Wistar rats. Billroth II resection (B-II group) was performed on 24 rats and Billroth I resection (B-I group) was performed on 22 rats. The incidence of cancer in the B-II group was 20.8%, though no cancer was noted in the B-I group. The incidences of the pseudopyloric gland, dilated gland and gastritis cystica profunda in the B-II group were significantly higher than those in the B-I group. The degree of mucosal atrophy was greater in the B-II group than in the B-I group. The stomal area in the B-II group had expansion of proliferative zone as well as increased S-phase duration and turn over time, compared with those in the B-I group. The sequence of histological and proliferative events associated with duodenogastric reflux suggests that the residual stomach in the B-II group is susceptible to the development of cancer.

• Authors: T Kamata
• Journal: Nihon Geka Gakkai zasshi (Nihon Geka Gakkai Zasshi) Vol. 94 Issue 2 Pg. 104-13 (Feb 1993) ISSN: 0301-4894 [Print] Japan
• PMID: 8464407 (Publication Type: Comparative Study, English Abstract, Journal Article)

Topics

• Animals
• Cell Cycle
• Duodenogastric Reflux (etiology)
• Gastrectomy (methods)
• Gastric Mucosa (pathology)
• Male
• Neoplasm Recurrence, Local (etiology, pathology)
• Rats
• Rats, Wistar
• Stomach Neoplasms (etiology, pathology, surgery)