Abstract | BACKGROUND: Increased intestinal macromolecular permeability could allow absorption of substances from the bowel into the systemic circulation and contribute to multiple organ system failure. METHODS: RESULTS: Gut permeability to polyethylene glycol 3350 ( PEG 3350) was increased in animals with early experimental pancreatitis (5.4% +/- 1.2%, n = 20) when compared with control animals (1.8% +/- 0.2%; n = 6) (P = 0.0005). Furthermore, intestinal macromolecular permeability to PEG 3350 correlated with severity of disease as predicted by the method of induction of pancreatitis (P = 0.0003), the histological findings (P = 0.0002), and total ascitic trypsinogen activation peptides content (P = 0.029). CONCLUSIONS:
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Authors | C M Ryan, J Schmidt, K Lewandrowski, C C Compton, D W Rattner, A L Warshaw, R G Tompkins |
Journal | Gastroenterology
(Gastroenterology)
Vol. 104
Issue 3
Pg. 890-5
(Mar 1993)
ISSN: 0016-5085 [Print] United States |
PMID | 8440440
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Animals
- Intestinal Mucosa
(metabolism)
- Intestines
(ultrastructure)
- Male
- Pancreas
(pathology)
- Pancreatitis
(metabolism, pathology)
- Permeability
- Polyethylene Glycols
(pharmacokinetics)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
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