[Effectiveness of the resorptive treatment of leptomeningitis (experimental study)].

Abstract

An introduction into the major cistern of the cranial ground of sterile talc to 134 rabbits artificially created a model of leptomeningitis. The talc evoked proliferative reactions of fiber and cellular structures adjacent to the area of pia mater. Treatment by 1 or 2 sessions of lydase, pyrogenal, bijochinol, bijochinol in combination with radiation therapy led to a significant decrease of the fibroplastic changes in the pia mater and liquordynamic pyrogenal. Bijochinol therapy did not exert any special effect. The convened studies confirm the effectiveness of resorptive therapy, thus permitting to recommend this form of therapy for the treatment of patients with arachnoiditis (leptomeningitis).

• Authors: I S Safonova
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 77 Issue 2 Pg. 190-5 ( 1977) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' rassasyvaiushchego lecheniia leptomeningita (éksperimental'noe issledovanie
• PMID: 842235 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Pyrogens
• Quinine
• Hyaluronoglucosaminidase

Topics

• Animals
• Arachnoid (pathology)
• Arachnoiditis (drug therapy, pathology, radiotherapy, therapy)
• Brain (pathology)
• Female
• Hyaluronoglucosaminidase (therapeutic use)
• Male
• Pyrogens (therapeutic use)
• Quinine (therapeutic use)
• Rabbits