Abstract |
We performed a preliminary phase II clinical trial of MX2; 3'-deamino-3'-morpholino-13-deoxy-10-hydroxycarminomycin (KRN8602) in patients with metastatic breast cancer who had failed to respond to previous chemotherapeutic regimens after clinical evidence of systemic disease. Twelve patients at a single institute received KRN8602 at a dose of 35 mg/m2 intravenously once every three weeks. All the patients were followed-up until their disease progressed. There was one complete response lasting 17 weeks and one partial response lasting eight weeks. Among the 12 patients, World Health Organization (WHO) grades 3 and 4 neutropenia were observed in five and two patients, respectively. Grade 3 anemia was observed in three patients but severe thrombocytopenia was not observed. Grade 3 nausea/ vomiting was observed in eight patients. Alopecia was not observed. The results of this preliminary phase II trial suggest a need for further testing of the anti- tumor activity of KRN8602 in patients with metastatic breast cancer.
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Authors | T Watanabe, M Narabayashi, S Haga, Y Yamada, E Kawamura, K Enomoto, M Kusama, K Kimura, I Adachi, O Abe |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 23
Issue 4
Pg. 246-9
(Aug 1993)
ISSN: 0368-2811 [Print] England |
PMID | 8411738
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- morpholinoanthracycline MX2
- Carubicin
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Topics |
- Antibiotics, Antineoplastic
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy)
- Carubicin
(adverse effects, analogs & derivatives, therapeutic use)
- Female
- Humans
- Middle Aged
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