Anti-arrhythmic effects of a new calcium antagonist, monatepil, AJ-2615, in experimental arrhythmic models [corrected].

Abstract

1. To characterize the anti-arrhythmic properties of a new calcium antagonist, monatepil [corrected], AJ-2615, the preventive effects of AJ-2615 were compared with those of the existing calcium antagonists, diltiazem and verapamil, in experimental models of arrhythmia. 2. AJ-2615 (0.1-3.0 mg/kg, i.v.) suppressed ventricular arrhythmias induced by adrenaline (10 micrograms/kg, i.v.) in rats. AJ-2615 (0.1 mg/kg per min for 2 min, i.v.) also suppressed atrial tachycardia induced by aconitine (0.01% aconitine solution) in rats. 3. In these activities, AJ-2615 was comparable to or more potent than diltiazem and verapamil which are widely used for the treatment of arrhythmia. 4. In pro-arrhythmic activity, AJ-2615 was less potent than diltiazem and verapamil. 5. These results suggest that AJ-2615 would be a safer anti-arrhythmic agent, with less proarrhythmic liability than diltiazem and verapamil.

• Authors: T Yamamoto, K Hosoki, T Karasawa
• Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) 1993 Jul-Aug Vol. 20 Issue 7-8 Pg. 497-500 ISSN: 0305-1870 [Print] Australia
• PMID: 8403530 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Calcium Channel Blockers
• Dibenzothiepins
• Piperazines
• Verapamil
• Diltiazem
• monatepil
• Aconitine
• Epinephrine

Topics

• Aconitine (toxicity)
• Animals
• Arrhythmias, Cardiac (chemically induced, drug therapy)
• Calcium Channel Blockers (administration & dosage, therapeutic use, toxicity)
• Dibenzothiepins (administration & dosage, therapeutic use, toxicity)
• Diltiazem (administration & dosage, therapeutic use, toxicity)
• Disease Models, Animal
• Epinephrine (toxicity)
• Injections, Intravenous
• Male
• Piperazines (administration & dosage, therapeutic use, toxicity)
• Rats
• Rats, Wistar
• Tachycardia (drug therapy, prevention & control)
• Verapamil (administration & dosage, therapeutic use, toxicity)