Verucopeptin, a new antitumor antibiotic active against B16 melanoma. I. Taxonomy, production, isolation, physico-chemical properties and biological activity.

Abstract	A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It should potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D x 1 treatment schedule.
Authors	Y Nishiyama, K Sugawara, K Tomita, H Yamamoto, H Kamei, T Oki
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 46 Issue 6 Pg. 921-7 (Jun 1993) ISSN: 0021-8820 [Print] England
PMID	8344873 (Publication Type: Journal Article)
Chemical References	Antibiotics, Antineoplastic Depsipeptides Peptides, Cyclic verucopeptin
Topics	Actinomycetales (chemistry) Animals Antibiotics, Antineoplastic (chemistry, isolation & purification, pharmacology) Chromatography, High Pressure Liquid Depsipeptides Fermentation Humans Leukemia L1210 (drug therapy) Leukemia P388 (drug therapy) Male Melanoma, Experimental (drug therapy) Mice Microbial Sensitivity Tests Peptides, Cyclic (chemistry, isolation & purification, pharmacology)

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