Benzylideneascorbate induces apoptosis in L929 tumor cells.

Abstract

Sodium 5,6-benzylideneascorbate (SBA), which is known to be an antitumor substance, was found to induce apoptotic cell death of L929 tumor cells directly in a concentration- and time-dependent manner. The dying cells exhibited cell shrinkage, disappearance of cell surface microvilli, chromatin condensation and DNA fragmentation into nucleosomal oligomers characteristic of apoptosis. These results indicate a possible mechanism by which SBA induces tumor regression in vivo.

• Authors: S Tanuma, D Shiokawa, Y Tanimoto, M Ikekita, H Sakagami, M Takeda, S Fukuda, M Kochi
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 194 Issue 1 Pg. 29-35 (Jul 15 1993) ISSN: 0006-291X [Print] United States
• PMID: 8333843 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzylidene Compounds
• DNA, Neoplasm
• Ascorbic Acid
• zilascorb

Topics

• Animals
• Antineoplastic Agents (toxicity)
• Apoptosis (drug effects)
• Ascorbic Acid (analogs & derivatives, toxicity)
• Benzylidene Compounds (toxicity)
• DNA Damage
• DNA, Neoplasm (drug effects, isolation & purification)
• Electrophoresis, Agar Gel
• Fibrosarcoma (pathology, ultrastructure)
• Kinetics
• Mice
• Microscopy, Electron
• Molecular Structure
• Tumor Cells, Cultured