[Clinical evaluation of S-1108 in children].

Abstract

A new oral cephem antibiotic, S-1108, was evaluated for its clinical efficacy and safety in children. S-1108 was effective in 95% of the 59 examined cases of respiratory, middle ear, skin and urinary tract infections. S-1108 was highly effective in infections of Streptococcus pyogenes, Haemophilus influenzae and Escherichia coli, but was less effective in penicillin-resistant Streptococcus pneumoniae and Staphylococcus aureus infections. The serum half-life was 1.26 +/- 0.36 hours upon after meal administration of 4 mg/kg. No severe adverse reaction was encountered. From these data, S-1108 appears to be safe and effective in children with susceptible bacterial infections.

• Authors: H Meguro, A Mori, R Fujii, I Terashima
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 46 Issue 11 Pg. 959-66 (Nov 1993) ISSN: 0368-2781 [Print] Japan
• PMID: 8309072 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• S 1108

Topics

• Bacterial Infections (drug therapy, metabolism, microbiology)
• Cephalosporins (pharmacokinetics, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Escherichia coli Infections (drug therapy)
• Female
• Haemophilus Infections (drug therapy)
• Haemophilus influenzae
• Humans
• Infant
• Male
• Respiratory Tract Infections (drug therapy, metabolism, microbiology)
• Streptococcal Infections (drug therapy)
• Streptococcus pyogenes
• Urinary Tract Infections (drug therapy, metabolism, microbiology)