[Antioxidant activity of a new derivative of 4-hydrazinoquinazoline in experimental cerebral hypoxia].

Abstract

It is established that KS-79 compound possesses the high level of antioxidant activity and realizes its antioxidant effect at initial stages of free-radical hydrogen peroxide oxidation of lipids. Due to this ability it differs from the oxidants of direct-type action.

• Authors: V V Dunaev, I F Belenichev, S I Kovalenko, I A Mazur, R S Siniak, I N Bashkin, V S Tishkin
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1993 May-Jun Vol. 65 Issue 3 Pg. 118-20 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Antioksidantnaia aktivnost'novogo proizvodnogo 4-gidrazinokhinazolina pri éksperimental'noĭ gipoksii golovnogo mozga.
• PMID: 8291133 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Free Radicals
• Hydrazines
• Quinazolines
• Quinazolinones
• Vitamin E
• 4-hydrazinoquinazoline

Topics

• Animals
• Antioxidants (pharmacology)
• Brain Ischemia (drug therapy, metabolism)
• Free Radicals
• Hydrazines (pharmacology)
• Hypoxia, Brain (drug therapy, metabolism)
• Lipid Peroxidation (drug effects)
• Male
• Quinazolines (pharmacology)
• Quinazolinones
• Rats
• Rats, Wistar
• Vitamin E (metabolism)