Carcinogenesis in Sprague-Dawley rats of N-nitroso-N-alkylcarbamate esters.

Abstract

Nitrosocarbaryl, nitroso-N-methylurethane and nitroso-N-ethylurethane were administered by gavage in olive oil solution to groups of 12 female Sprague-Dawley rats. The dose was 0.2 ml of 0.11 M solution once a week for 10 weeks, a total dose of 0.22 mmol. The rats given nitrosocarbaryl survived longer, but had as high an incidence of tumors (75%) as did rats given nitrosomethylurethane. Most of the tumors induced were invasive squamous carcinomas of the stomach. Nitrosoethylurethane appeared to be a little more potent than nitrosomethylurethane; all 12 animals in this group had squamous stomach tumors at death. A higher total dose of nitrosocarbaryl, 1.3 mmol, given to male rats twice weekly for 20 weeks did not produce a higher incidence of stomach tumors than did thelower dose in females, although the males died earlier with tumors.

• Authors: W Lijinsky, H W Taylor
• Journal: Cancer letters (Cancer Lett) Vol. 1 Issue 5 Pg. 275-9 (May 1976) ISSN: 0304-3835 [Print] Ireland
• PMID: 828074 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nitrosamines
• Nitroso Compounds
• Urethane
• Nitrosomethylurethane
• nitrosocarbaryl
• Carbaryl

Topics

• Administration, Oral
• Administration, Topical
• Animals
• Carbaryl (administration & dosage, analogs & derivatives, toxicity)
• Carcinoma, Squamous Cell (chemically induced)
• Female
• Neoplasms, Experimental (chemically induced)
• Nitrosamines
• Nitroso Compounds (administration & dosage, toxicity)
• Nitrosomethylurethane (analogs & derivatives, toxicity)
• Rats
• Skin Neoplasms (chemically induced)
• Stomach Neoplasms (chemically induced)
• Urethane (analogs & derivatives)