Influence of immunoadsorption on the removal of immunoglobulin G autoantibodies in crescentic glomerulonephritis.

Abstract

We report the treatment of 5 patients with crescentic glomerulonephritis by immunoadsorption using a protein A column. Two had systemic vasculitis, 2 antiglomerular basement membrane disease and 1 systemic lupus erythematosus (SLE). In the patients with systemic vasculitis and SLE, there was successful removal of autoantibodies and rapid control of disease; remission was maintained over a mean follow-up of 2 years. Clinical improvement was not seen in 2 patients with anti-glomerular basement membrane (GBM) disease who presented with dialysis-dependent renal failure. There were no apparent clinical side-effects related to the immunoadsorption procedure. Protein A immunoadsorption offers a semiselective alternative to plasma exchange and appears to be safe and efficient in removing pathogenic autoantibodies in crescentic glomerulonephritis without anti-GBM antibodies.

• Authors: V L Esnault, A Testa, D R Jayne, J P Soulillou, J Guenel
• Journal: Nephron (Nephron) Vol. 65 Issue 2 Pg. 180-4 ( 1993) ISSN: 1660-8151 [Print] Switzerland
• PMID: 8247177 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies
• Autoantibodies
• Immunoglobulin G
• Staphylococcal Protein A
• antiglomerular basement membrane antibody

Topics

• Adolescent
• Adult
• Antibodies (immunology)
• Autoantibodies (isolation & purification)
• Extracorporeal Circulation
• Female
• Glomerulonephritis (immunology, therapy)
• Humans
• Immunoglobulin G (immunology, isolation & purification)
• Immunosorbent Techniques
• Kidney Diseases (immunology)
• Lupus Erythematosus, Systemic (immunology, therapy)
• Male
• Middle Aged
• Plasma Exchange
• Staphylococcal Protein A
• Vasculitis (immunology, therapy)