Antiplatelet therapy in the treatment of cerebrovascular disease.

Abstract

Aspirin and the new agent ticlopidine have been the most thoroughly evaluated of the platelet-antiaggregating drugs used for the prevention of stroke and other vascular events. Numerous trials have shown aspirin to be effective in reducing the risk of myocardial infarction (MI), recurrent transient ischemic attacks, stroke, and vascular death in men at high risk for these events. Primary prevention trials have shown that aspirin reduces the risk of MI in healthy men over 50 years of age but does not reduce the risk of stroke. Two large, multicenter trials have shown that ticlopidine is effective in reducing the risk of fatal and nonfatal stroke in both men and women. Ticlopidine may also be effective in reducing the risk of recurrent stroke in patients who have had a completed thromboembolic stroke.

• Authors: J R Couch
• Journal: Clinical cardiology (Clin Cardiol) Vol. 16 Issue 10 Pg. 703-10 (Oct 1993) ISSN: 0160-9289 [Print] United States
• PMID: 8222382 (Publication Type: Journal Article, Review)

Chemical References

• Platelet Aggregation Inhibitors
• Ticlopidine
• Aspirin

Topics

• Adult
• Aged
• Aspirin (therapeutic use)
• Cardiovascular Diseases (drug therapy)
• Cerebrovascular Disorders (drug therapy, epidemiology, prevention & control)
• Female
• Humans
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (therapeutic use)
• Randomized Controlled Trials as Topic
• Risk Factors
• Ticlopidine (therapeutic use)