Abstract |
The question as to whether or not topical medication with beta blockers causes a decrease in tear production remains unanswered. Earlier studies using filter-paper strip tests have yielded contradictory results. In the present study, computerized objective fluorophotometry was used to assess the effect of topical medication with 0.5% timolol (b.i.d.; OU) on tear volume and tear production in 24 consecutive patients with bilateral primary open-angle glaucoma. Tear-film fluorophotometry was performed before treatment as well as at 7 days, 14 days, and 4-7 months after the onset of treatment. The results showed that by 7 days after the initiation of timolol treatment, both tear volume (-29%, P < 0.01) and tear secretion (-36%, P < 0.01) had decreased significantly. However, at both 14 days and 4-7 months after the onset of treatment, none of the values differed significantly from those obtained before treatment. Thus, topical antiglaucomatous treatment with 0.5% timolol eye drops leads to a transient decrease in tear production. This effect, however, lasts no longer than 14 days after the beginning of treatment.
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Authors | M Göbbels, T Mönks, M Spitznas |
Journal | German journal of ophthalmology
(Ger J Ophthalmol)
Vol. 2
Issue 4-5
Pg. 241-5
(Aug 1993)
ISSN: 0941-2921 [Print] Germany |
PMID | 8220106
(Publication Type: Journal Article)
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Chemical References |
- Ophthalmic Solutions
- Timolol
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Topics |
- Administration, Topical
- Fluorophotometry
- Glaucoma, Open-Angle
(drug therapy, physiopathology)
- Humans
- Middle Aged
- Ophthalmic Solutions
- Tears
(metabolism)
- Timolol
(administration & dosage)
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