Abstract | BACKGROUND: METHODS: In a two-stage open sequential design, patients presenting for elective repeat cesarean section were allocated to receive either no preload or 20 ml/kg crystalloid administered over 15-20 min before spinal anesthesia. Hypotension was defined as a decrease in systolic pressure to less than 100 mmHg and to less than 80% of baseline value, and the study was designed to detect a 20% difference in the incidence of hypotension between the groups, with statistical significance at the 10% (alpha = 0.1) level, one-tailed. RESULTS: One hundred forty patients were studied. Hypotension occurred in 43 (55%, 95% CI 43.4-66.4) preloaded and 44 (71%, 95% CI 58-81.8) unpreloaded subjects, a difference in incidence of 16% (95% CI 0.04-31.6), which was statistically significant. There were no significant differences in the severity, timing, or duration of hypotension; the dose requirement for ephedrine; or the clinical and biochemical status of neonates between the groups. The only difference seen was a lower mean base excess (-3.4, SD 2.81 mM-1) in the neonates of hypotensive mothers compared to neonates of nonhypotensive mothers (-2.4, SD 1.99 mM-1). CONCLUSIONS:
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Authors | C C Rout, D A Rocke, J Levin, E Gouws, D Reddy |
Journal | Anesthesiology
(Anesthesiology)
Vol. 79
Issue 2
Pg. 262-9
(Aug 1993)
ISSN: 0003-3022 [Print] United States |
PMID | 8192733
(Publication Type: Journal Article)
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Chemical References |
- Crystalloid Solutions
- Isotonic Solutions
- Plasma Substitutes
- Bupivacaine
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Topics |
- Adult
- Anesthesia, Obstetrical
(adverse effects)
- Anesthesia, Spinal
(adverse effects)
- Blood Pressure
(drug effects)
- Bupivacaine
- Cesarean Section
- Crystalloid Solutions
- Evaluation Studies as Topic
- Female
- Heart Rate
(drug effects)
- Humans
- Hypotension
(etiology, prevention & control)
- Isotonic Solutions
- Plasma Substitutes
(therapeutic use)
- Preanesthetic Medication
- Pregnancy
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