Abstract |
A retrospective study of all premature neonates who received artificial surfactant ( Curosurf) at the Rotunda Hospital was performed. The period from October 1990 to June 1992 (n = 48) was compared with the initial experience from June 1987 to January 1988 (n = 15). In the initial period mortality rate was 67% in surfactant treated infants, and use of surfactant was not associated with an improvement in outcome compared with the previous six years. In the more recent period overall mortality was 21%. Overall survival in normally formed very low birthweight infants improved from 59% in 1986 to 86% in 1991-1992. Improvement in survival rates was most noticeable in infants with birthweight 750-999 grams, with survival increasing from 44% (before introduction of surfactant treatment) to 91% (in 1991-1992). It is probable that a certain level of experience with use of surfactant is required before optimal effects can be obtained.
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Authors | S M Gormally, T A Clarke, A Krishnan, M Ali, T G Matthews |
Journal | Irish journal of medical science
(Ir J Med Sci)
Vol. 162
Issue 11
Pg. 458-61
(Nov 1993)
ISSN: 0021-1265 [Print] Ireland |
PMID | 8113035
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Female
- Humans
- Infant, Low Birth Weight
- Infant, Newborn
- Male
- Respiratory Distress Syndrome, Newborn
(drug therapy, mortality)
- Retrospective Studies
- Surface-Active Agents
(therapeutic use)
- Survival Rate
- Treatment Outcome
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