Reversal of inherent multidrug-resistance in primary human renal cell carcinoma cell cultures by S 9788.

Abstract

In a panel of 14 primary cultures of human renal cell carcinomas the reversal of inherent multidrug-resistance by S 9788, a new triazinoaminopiperidine derivative, was analysed. In combination with doxorubicin S 9788 revealed an evident reversal of multidrug resistance in 12 cell cultures. Two cell cultures remained unaffected. An association between reversal and P-glycoprotein (P-170) expression suggests that S 9788 exerts its activity through P-glycoprotein.

• Authors: T Efferth, T A Dunn, M Berlion, H Langenbahn, E W Pommerenke, M Volm
• Journal: Anticancer research (Anticancer Res) 1993 Jul-Aug Vol. 13 Issue 4 Pg. 905-8 ISSN: 0250-7005 [Print] Greece
• PMID: 8102519 (Publication Type: Journal Article)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Antineoplastic Agents
• Carrier Proteins
• Membrane Glycoproteins
• Piperidines
• Triazines
• S 9788
• Doxorubicin

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Animals
• Antineoplastic Agents (toxicity)
• Carcinoma, Renal Cell
• Carrier Proteins (analysis, biosynthesis)
• Cell Division (drug effects)
• Dose-Response Relationship, Drug
• Doxorubicin (toxicity)
• Drug Interactions
• Drug Resistance (physiology)
• Humans
• Kidney Neoplasms
• Kinetics
• Membrane Glycoproteins (analysis, biosynthesis)
• Mice
• Piperidines (toxicity)
• Sarcoma 180
• Triazines (toxicity)
• Tumor Cells, Cultured