Effect of erythrocytes treated with enterobacterial common antigen on experimental Salmonella typhimurium infection of mice.

Abstract

The immunogenicity of enterobacterial common antigen (CA)-treated horse or mouse erythrocytes was determined in Swiss white albino mice by comparing survival rates with control mice, immunized with P. aeruginosa fraction-treated RBC and challenged in parallel with 10 LD50 S. typhimurium. The administration of small amounts of CA on horse, but not mouse, RBC significantly delayed mortality; protection was only marginally less than that evoked with 12-fold larger amounts of CA in the absence of RBC. Survival in infected animals was transient; independent of immunogen or control preparation employed, all mice were dead by day 15 after challenge.

• Authors: E A Gorzynski, S A Krasny
• Journal: Medical microbiology and immunology (Med Microbiol Immunol) Vol. 161 Issue 3 Pg. 163-70 (Jul 02 1975) ISSN: 0300-8584 [Print] Germany
• PMID: 809654 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antigens, Bacterial

Topics

• Animals
• Antigens, Bacterial
• Erythrocytes
• Horses
• Immunization
• Male
• Mice
• Pseudomonas aeruginosa
• Salmonella Infections, Animal (immunology)
• Salmonella typhimurium
• Time Factors