Abstract |
Serum 25-hydroxyvitamin D [25( OH)D], calcium, phosphorus, and alkaline phosphatase activities were measured from birth to 6-9 mo of age in 60 healthy neonates to assess the effectiveness and potential toxicity of three intermittent oral doses of cholecalciferol. Two weeks after a first dose of 15, 5, or 2.5 mg, 25( OH)D concentrations reached 307 +/- 160, 150 +/- 55, and 92 +/- 42 nmol/L, respectively. Prolonged vitamin D overload, up to 6 mo, was found in 50% of the children given 15 mg, but not in the other infants. Serum calcium transiently increased 2 wk after 15 mg but not after the lower doses. Oral doses of 2.5 mg given every 3 mo appear to provide the best protection against vitamin D deficiency and vitamin D overload in high-risk infant populations that are unsuitable for daily vitamin D supplementation.
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Authors | F Zeghoud, H Ben-Mekhbi, N Djeghri, M Garabédian |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 60
Issue 3
Pg. 393-6
(Sep 1994)
ISSN: 0002-9165 [Print] United States |
PMID | 8074071
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Cholecalciferol
- 25-Hydroxyvitamin D 2
- Phosphorus
- Alkaline Phosphatase
- Calcifediol
- Calcium
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Topics |
- 25-Hydroxyvitamin D 2
(blood)
- Administration, Oral
- Alkaline Phosphatase
(blood)
- Calcifediol
(blood)
- Calcium
(blood)
- Cholecalciferol
(administration & dosage, adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Humans
- Infant, Newborn
- Longitudinal Studies
- Phosphorus
(blood)
- Vitamin D Deficiency
(prevention & control)
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