Abstract |
Availability of arbekacin (ABK) was analyzed in the chemotherapy of 24 MRSA-infected patients with symptoms of pneumonia (12), sepsis (6) and others (6). Most patients had background diseases such as malignant tumors or cerebrovascular disorders. 47% (7/15) of them were immunologically abnormal. 17 of them had been previously treated with cephems, imipenem, minocycline or fosfomycin. The ABK therapy was performed with doses ranging 50-400 mg a day, divided into 1-3 times (mostly 100 mg x 2), and for 5-24 days. (18 patients were treated between 5 and 14 days). 14 patients (58%) received combined therapy with other antibiotics (mostly with beta-lactams, 12). The clinical efficacy rate of the ABK therapy was 62% (good, 13; fair, 4; ineffective, 4; unknown, 3). The bacteriological efficacies were: eradicated, 7 (44%); decreased, 4; no change, 5; unknown, 8. Side effects were found in 3 patients ( oliguria, 2; eruption due to drug, 1) and one case resulted in serious renal disorder. Abnormal laboratory data were found in 7 cases. Above results have indicated that ABK is a useful antibiotic in chemotherapy of MRSA- infections.
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Authors | S Odagiri, M Sumitomo, K Takahashi, F Matsumoto, I Sakurai, T Imai, K Yoshikawa, A Ito, M Sugiyama, M Suzuki |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 47
Issue 6
Pg. 751-62
(Jun 1994)
ISSN: 0368-2781 [Print] Japan |
PMID | 8072184
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Aminoglycosides
- Anti-Bacterial Agents
- Dibekacin
- arbekacin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aminoglycosides
- Anti-Bacterial Agents
- Bacteremia
(drug therapy, microbiology)
- Dibekacin
(adverse effects, analogs & derivatives, therapeutic use)
- Drug Therapy, Combination
(therapeutic use)
- Female
- Humans
- Kidney
(drug effects)
- Male
- Methicillin Resistance
- Middle Aged
- Pneumonia, Staphylococcal
(drug therapy, microbiology)
- Staphylococcal Infections
(drug therapy, microbiology)
- Staphylococcus aureus
(drug effects, isolation & purification)
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