[Morphologic rationale for selecting composition and structure of biologically active material based on sodium alginate for wound treatment].

Abstract

Morphological evaluation of composition and structure of a biologically active compound (BAC) based on sodium alginate, comprising 1% sizomycin and 0.25% protease C, on wound healing in infected rats wounds was made in experiment. The results have clearly shown that for the infected wound treatment during the first period of wound healing BAC of polyfunctional action must be applied. Biologically active substances (sizomycin and protease C) promote removal of inflammatory etiopathogenic factors, i. e. necrotic tissues and microbic bodies, while polysaccharide basis of the composition promotes stimulation of reparative processes in the wounds. Powder with granules size 315 m including 24% potassium gluconate is believed most suitable BAC structure.

• Authors: S P Gliantsev, A G Annaev, T V Savvina
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 115 Issue 1 Pg. 65-7 (Jan 1993) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Morfologicheskoe obosnovanie vybora sostava i struktury biologicheski aktivnoĭ kompozitsii na osnove al'ginata natriia dlia lecheniia ran.
• PMID: 8054584 (Publication Type: Journal Article)

Chemical References

• Alginates
• Drug Combinations
• Hexuronic Acids
• Glucuronic Acid
• Endopeptidases
• protease S
• Sisomicin

Topics

• Alginates (administration & dosage)
• Animals
• Drug Combinations
• Endopeptidases
• Glucuronic Acid
• Hexuronic Acids
• Necrosis
• Rats
• Sisomicin (administration & dosage)
• Wound Healing (drug effects)
• Wound Infection (drug therapy, pathology, physiopathology)