Studies on the effect of short-term oral dihydroergotamine and troxerutin in patients with varicose veins.

Abstract

OBJECTIVE:

To evaluate the clinical efficacy and pharmacologic effects of dihydroergotamine and troxerutin on varicose veins.

METHODS:

A double-blind, randomized, placebo-controlled parallel-group study was conducted in 53 patients with primary varicose veins. Patients received either a fixed combination of 3 mg dihydroergotamine and 300 mg troxerutin three times a day or placebo for 3 weeks. Symptomatic improvement was assessed by a self-assessment score, venocontracting effects on a varicose vein were quantified by the venous compliance technique (VCT), and changes in venous dysfunction were measured by digital photoplethysmography (DPPG).

RESULTS:

A significant reduction (p < 0.01) of subjective symptoms was observed in both groups. Results from VCT and DPPG after the therapy with dihydroergotamine and troxerutin or placebo were not significantly different (p > 0.05) from pretreatment values. Furthermore, no significant intergroup difference was observed when the before- and after-therapy differences of values of the self-assessment scores (VCT and DPPG) were compared.

CONCLUSION:

In our study, 3 weeks of treatment with a fixed drug combination of 3 mg dihydroergotamine plus 300 mg troxerutin three times a day had no measurable effect compared with placebo on any of the evaluated end points.

• Authors: S Schuller-Petrovic, M Wolzt, K Böhler, B Jilma, H G Eichler
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 56 Issue 4 Pg. 452-9 (Oct 1994) ISSN: 0009-9236 [Print] United States
• PMID: 7955807 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxyethylrutoside
• Vasoconstrictor Agents
• Dihydroergotamine
• troxerutin

Topics

• Adult
• Dihydroergotamine (administration & dosage)
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Humans
• Hydroxyethylrutoside (administration & dosage, analogs & derivatives)
• Male
• Middle Aged
• Photoplethysmography (methods)
• Time Factors
• Varicose Veins (drug therapy, physiopathology)
• Vasoconstrictor Agents (administration & dosage)