Abstract |
Idoxifene, a novel antiestrogen with reduced estrogenic activity when compared to tamoxifen, has been given to 20 women with metastatic breast cancer, 19 of whom had received tamoxifen previously, in doses between 10-60 mg. Idoxifene had an initial half-life of 15 h and a terminal half-life of 23.3 days. At a maintenance dose of 20 mg, a mean steady-state level of 173.5 ng/ml was achieved. Significant falls in luteinizing hormone and follicle-stimulating hormone were seen, but the falls were not dose related. Idoxifene was well tolerated, with 11 patients complaining of mild symptoms similar to those seen with tamoxifen. Fourteen patients continued idoxifene therapy for 1-56 weeks; 4 patients showed stabilization of disease for 6-56 weeks and 2 patients showed a partial response.
|
Authors | R C Coombes, B P Haynes, M Dowsett, M Quigley, J English, I R Judson, L J Griggs, G A Potter, R McCague, M Jarman |
Journal | Cancer research
(Cancer Res)
Vol. 55
Issue 5
Pg. 1070-4
(Mar 01 1995)
ISSN: 0008-5472 [Print] United States |
PMID | 7866990
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Comparative Study, Journal Article, Multicenter Study)
|
Chemical References |
- Estrogen Antagonists
- Tamoxifen
- idoxifene
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
(drug therapy, metabolism, pathology)
- Endocrine Glands
(drug effects)
- Estrogen Antagonists
(adverse effects, pharmacokinetics, therapeutic use)
- Female
- Humans
- Middle Aged
- Neoplasm Metastasis
- Postmenopause
- Tamoxifen
(adverse effects, analogs & derivatives, pharmacokinetics, therapeutic use)
|