Abstract | BACKGROUND: Mutations of mitochondrial DNA have been demonstrated as causes of human mitochondrial diseases. While these disorders typically involve multiple organs, the effect of mitochondrial mutations on the heart has not been systematically studied. METHODS AND RESULTS: CONCLUSIONS: The clinical features of cardiac involvement in mitochondrial diseases vary in the different subgroups of these disorders. Particular mitochondrial mutations can cause characteristic cardiac abnormalities.
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Authors | R Anan, M Nakagawa, M Miyata, I Higuchi, S Nakao, M Suehara, M Osame, H Tanaka |
Journal | Circulation
(Circulation)
Vol. 91
Issue 4
Pg. 955-61
(Feb 15 1995)
ISSN: 0009-7322 [Print] United States |
PMID | 7850981
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Arrhythmias, Cardiac
(diagnosis, genetics)
- Blotting, Southern
- Cardiomegaly
(diagnosis, genetics)
- Cardiomyopathy, Dilated
(diagnosis, genetics)
- DNA, Mitochondrial
(genetics)
- Echocardiography
- Electrocardiography
- Female
- Heart Conduction System
(physiopathology)
- Heart Diseases
(diagnosis, genetics)
- Humans
- Male
- Mitochondrial Encephalomyopathies
(complications, genetics)
- Point Mutation
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