Crown-rump length in chromosomally abnormal fetuses at 10 to 13 weeks' gestation.

Abstract

OBJECTIVE:

Our purpose was to investigate whether fetuses with aneuploidies demonstrate evidence of growth retardation during the first trimester.

STUDY DESIGN:

This was a retrospective, cross-sectional study of singleton pregnancies undergoing fetal karyotyping at 10 to 13 weeks' gestation. Measurements of crown-rump length in 135 chromosomally abnormal fetuses were compared with those in 700 chromosomally normal fetuses.

RESULTS:

The median crown-rump length of fetuses with trisomy 18 (n = 32) was significantly reduced. In contrast, in fetuses with trisomy 21 (n = 72), trisomy 13 (n = 11), 47,XXX (n = 6), 47,XXY (n = 6), 45,X (n = 5), and triploidy (n = 3) the crown-rump length was not lower than normal.

CONCLUSION:

At 10 to 13 weeks' gestation fetuses with trisomy 18 are growth retarded, whereas in trisomy 21, trisomy 13, and sex chromosome aneuploidy growth is normal.

• Authors: P Kuhn, M L Brizot, P P Pandya, R J Snijders, K H Nicolaides
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 172 Issue 1 Pt 1 Pg. 32-5 (Jan 1995) ISSN: 0002-9378 [Print] United States
• PMID: 7847557 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Chromosome Aberrations (pathology)
• Chromosome Disorders
• Chromosomes, Human, Pair 13
• Chromosomes, Human, Pair 18
• Chromosomes, Human, Pair 21
• Cross-Sectional Studies
• Crown-Rump Length
• Female
• Fetus (anatomy & histology)
• Gestational Age
• Humans
• Ploidies
• Pregnancy
• Pregnancy Trimester, First
• Retrospective Studies
• Trisomy