The pattern of neuronal injury following seizures induced by intranigral kainic acid.

Abstract

The substantia nigra pars reticulosa (SNpr) is involved in the initiation and propagation of seizures within the limbic system (cingulate and parahippocampal gyri and associated connections in the brain stem, e.g. amygdala, hypothalamus, some thalamic nuclei, and parts of basal ganglia). We have investigated the pattern of neuronal injury (using heat shock protein (HSP) expression) and cell death (acid-fuchsin (AF) staining) in SNpr and limbic structures following seizures evoked by bilateral intranigral injection of kainic acid. Affected cells were observed predominantly in piriform cortex, amygdala, hippocampal formation, and thalamic nuclei; massive necrosis or hemorrhage occurred in bilateral piriform cortices following prolonged seizures. The piriform cortex may play an important role in the activation of limbic seizures under the regulation of the SNpr.

• Authors: K Tanaka, R P Simon
• Journal: Neuroscience letters (Neurosci Lett) Vol. 176 Issue 2 Pg. 205-8 (Aug 01 1994) ISSN: 0304-3940 [Print] Ireland
• PMID: 7830948 (Publication Type: Journal Article)

Chemical References

• HSP70 Heat-Shock Proteins
• Kainic Acid

Topics

• Animals
• Behavior, Animal (drug effects)
• Cell Death (drug effects)
• Electroencephalography (drug effects)
• HSP70 Heat-Shock Proteins (biosynthesis)
• Histocytochemistry
• Injections
• Kainic Acid (administration & dosage)
• Male
• Neurons (physiology)
• Rats
• Rats, Sprague-Dawley
• Seizures (chemically induced, pathology)
• Substantia Nigra