[Therapeutic results with the combination pramiverine/metamizole in a multicentre trial (author's transl)].

Abstract

279 physicians took part in a multicentre trial to assess the efficacy and acceptability of the combination of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) and N-methyl-N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-aminomethanesulfonate (metamizole) (Sistalgin comp) in the forms of ampoules, coated tablets and suppositories. 1301 out of 1329 case reports could be evaluated; in 28 cases treatment was discontinued. The trial included 59% acute colics and 41% subacute recurrent painful spasms of the caval organs. A single presentation form was used in 44%; all other patients were treated with the combined regimen of ampoules/coated tablets/suppositories. A good or very good result was obtained in 91% of cases, with a low rate of undesired side-effects. In 3%, the result was unsatisfactory. The patients' judgment was in agreement with that of the physician. Both judgments confirmed the rapid onset, long duration and reliable effect of pramiverine/metamizole in treating colics of the intestinal, biliary and urinary tracts as well as recurrent spastic pain. Similarly favourable results were obtained with all presentation forms.

• Authors: E Koch, W Eisele
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 26 Issue 4b Pg. 745-52 (Apr 1976) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Therapieergebnisse mit der Kombination Pramiverin/metamizol in einem Feldversuch
• PMID: 782472 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Benzhydryl Compounds
• Cyclohexylamines
• Drug Combinations
• Parasympatholytics
• Aminopyrine
• Dipyrone

Topics

• Adolescent
• Adult
• Aged
• Aminopyrine (analogs & derivatives)
• Benzhydryl Compounds (adverse effects, therapeutic use)
• Biliary Tract Diseases (drug therapy)
• Child
• Clinical Trials as Topic
• Colic (drug therapy)
• Cyclohexylamines (adverse effects, therapeutic use)
• Dipyrone (adverse effects, therapeutic use)
• Drug Combinations
• Dysmenorrhea (drug therapy)
• Female
• Gastrointestinal Diseases (drug therapy)
• Humans
• Middle Aged
• Parasympatholytics (adverse effects, therapeutic use)
• Spasm (drug therapy)
• Urologic Diseases (drug therapy)