Abstract |
We have recently developed synthetic low molecular weight inhibitors of both tissue and plasma kallikreins. Several of these were evaluated in vivo in the ovalbumin-sensitised guinea pig for their ability to prevent the bronchoconstriction elicited by antigen challenge. The selective tissue kallikrein inhibitor CH-694 (but not the selective plasma kallikrein inhibitor CH-684) caused highly significant falls in airways resistance when it was administered at 10 mg/kg intraperitoneally 15 min before and 90 min after challenge. There was also a highly significant fall in the tissue kallikrein activity measured in broncho-alveolar lavage fluid. Inhibitors of tissue kallikrein may prove effective in the treatment of allergic inflammation in man.
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Authors | M Szelke, D M Evans, D M Jones, L Fawcett, D Ashworth, H Olsson, R L Featherstone, M K Church |
Journal | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
(Braz J Med Biol Res)
Vol. 27
Issue 8
Pg. 1943-7
(Aug 1994)
ISSN: 0100-879X [Print] Brazil |
PMID | 7749385
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldehydes
- Ketones
- Peptides
- Ovalbumin
- Kallikreins
- Tissue Kallikreins
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Topics |
- Airway Resistance
(drug effects)
- Aldehydes
(pharmacology)
- Amino Acid Sequence
- Animals
- Bronchoalveolar Lavage Fluid
- Disease Models, Animal
- Guinea Pigs
- Hypersensitivity
(physiopathology)
- Inflammation
(physiopathology)
- Kallikreins
(antagonists & inhibitors, metabolism)
- Ketones
(pharmacology)
- Molecular Sequence Data
- Ovalbumin
(administration & dosage)
- Peptides
(pharmacology)
- Tissue Kallikreins
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