Is allopurinol beneficial in the prevention of renal ischaemia-reperfusion injury in the rat?: evaluation by near-infrared spectroscopy.

Abstract

1. The role of allopurinol in the protection of kidney function following ischaemia-reperfusion injury has been investigated using the novel technique of near-infrared spectroscopy. 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. 3. Allopurinol infusion increased the rate of reperfusion of oxygenated blood seen in control rats (P < 0.05). 4. Allopurinol enhanced the rate of tissue oxygenation during early reperfusion (P < 0.01). 5. This study provides further evidence for the proposed benefits of allopurinol in ischaemia-reperfusion injury. Furthermore, the potential of near-infrared spectroscopy as a technique of value in interventional studies of this nature is confirmed.

• Authors: D L Vaughan, Y A Wickramasinghe, G I Russell, M S Thorniley, R F Houston, E Ruban, P Rolfe
• Journal: Clinical science (London, England : 1979) (Clin Sci (Lond)) Vol. 88 Issue 3 Pg. 359-64 (Mar 1995) ISSN: 0143-5221 [Print] England
• PMID: 7736707 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hemoglobins
• Oxyhemoglobins
• Allopurinol

Topics

• Allopurinol (therapeutic use)
• Animals
• Hemoglobins (metabolism)
• Ischemia (blood, pathology, therapy)
• Kidney (blood supply, pathology)
• Male
• Oxyhemoglobins (metabolism)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (blood, pathology, prevention & control)