Abstract |
Goshajinkigan, a herbal medicine, has long been used in Japan to alleviate the subjective symptoms of diabetic neuropathy; however, its effects have not been confirmed objectively. We evaluated its effects on subjective symptoms and on vibration sensation in patients with diabetic neuropathy. The oral administration of 7.5 g/day of Goshajinkigan for 3 months (treatment period) relieved subjective symptoms of numbness in 9 of 13 patients. When the drug was discontinued for 2 months as a washout period, the subjective symptom worsened in 7 of 13 patients. Chi-square analysis revealed significant effects of Goshajiniagan on subjective symptoms (P < 0.001 for numbness and P < 0.05 for cold sensation). Vibration sensation was evaluated by measuring vibratory threshold using an SMV-5 vibrometer. There were significant changes in vibratory thresholds by paired t-test (P < 0.05) both in the upper and the lower extremities during the treatment and washout periods. Chi-square analysis also revealed a significant effect of Goshajinkigan on vibratory threshold (P < 0.01). There was no significant change in glycosylated hemoglobin as a whole during the study. These observations confirm that Goshajinkigan relieves subjective symptoms and demonstrate that it improves vibration sensation in patients with diabetic neuropathy.
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Authors | M Tawata, A Kurihara, K Nitta, E Iwase, N Gan, T Onaya |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 26
Issue 2
Pg. 121-8
(Dec 16 1994)
ISSN: 0168-8227 [Print] Ireland |
PMID | 7705193
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Topics |
- Administration, Oral
- Adult
- Aged
- Chi-Square Distribution
- Diabetic Neuropathies
(drug therapy, physiopathology)
- Female
- Humans
- Male
- Middle Aged
- Phytotherapy
- Sensory Thresholds
- Vibration
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