Serial IMP-SPECT and EEG studies in an infant with hemimegalencephaly.

Abstract

An 8-month-old girl of hypomelanosis of Ito associated with hemimegalencephaly had frequent seizures beginning 44 h after birth. The seizures were secondarily generalized or unilateral initially, followed by infantile spasms at about 1.5 months of age. Frequent partial seizures appeared at 4 months of age. [123I]N-Isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) was performed serially during an interictal period at 1, 3 and 7 months of age. At 1 and 3 months, IMP-SPECT showed a marked increase of IMP uptake in the pathological left hemisphere and electroencephalography (EEG) revealed left-sided dominant hypsarrhythmia. At 7 months of age, a reversal was seen, there being decreased uptake on SPECT in the pathological hemisphere and abundant high amplitude background activity mingled with epileptic discharges on EEG in the non-pathological hemisphere. These serial changes of IMP uptake on SPECT seemed to reflect either changes in epileptic activity or maturational changes in cerebral perfusion in hemimegalencephaly.

• Authors: T Tagawa, K Otani, Y Futagi, A Wakayama, K Morimoto, Y Morita
• Journal: Brain & development (Brain Dev) 1994 Nov-Dec Vol. 16 Issue 6 Pg. 475-9 ISSN: 0387-7604 [Print] Netherlands
• PMID: 7694999 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amphetamines
• Iodine Radioisotopes
• Iofetamine

Topics

• Age Factors
• Amphetamines
• Brain (abnormalities, diagnostic imaging, physiopathology)
• Electroencephalography
• Epilepsy (diagnosis, diagnostic imaging)
• Female
• Humans
• Infant
• Iodine Radioisotopes
• Iofetamine
• Tomography, Emission-Computed, Single-Photon