Chromosomal aberrations in cultured human lymphocytes treated with Marshal and its effective ingredient Carbosulfan.

Abstract

The aim of this study was to investigate the ability of Marshal (insecticide/nematocide) and its effective ingredient Carbosulfan to induce chromosomal aberrations (CA) and other chromosomal abnormalities in human peripheral lymphocytes. Carbosulfan induced the formation of CA at all concentrations (10(-6), 5 x 10(-6), 10(-5), 5 x 10(-5) v/v) and treatment times. Marshal significantly induced the formation of CA at the two highest concentrations (10(-5) and 5 x 10(-5) v/v) at all treatment times. The extent of damage was greatest with Carbosulfan.

• Authors: M Topaktaş, E Rencüzoğullar
• Journal: Mutation research (Mutat Res) Vol. 319 Issue 2 Pg. 103-11 (Oct 1993) ISSN: 0027-5107 [Print] Netherlands
• PMID: 7692285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbamates
• Insecticides
• carbosulfan

Topics

• Adult
• Carbamates (toxicity)
• Cells, Cultured
• Chromosome Aberrations
• Humans
• In Vitro Techniques
• Insecticides (toxicity)
• Lymphocytes (cytology, drug effects)
• Male
• Mutagenicity Tests