Abstract |
In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.
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Authors | S O Oh, B L Chang, J Lee |
Journal | Korean journal of ophthalmology : KJO
(Korean J Ophthalmol)
Vol. 9
Issue 1
Pg. 51-8
(Jun 1995)
ISSN: 1011-8942 [Print] Korea (South) |
PMID | 7674553
(Publication Type: Journal Article)
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Chemical References |
- Ophthalmic Solutions
- Mitomycin
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Topics |
- Administration, Topical
- Animals
- Chemotherapy, Adjuvant
- Conjunctiva
(drug effects)
- Mitomycin
(administration & dosage, pharmacology)
- Oculomotor Muscles
(drug effects, pathology, surgery)
- Ophthalmic Solutions
- Postoperative Complications
(prevention & control)
- Rabbits
- Sclera
(drug effects)
- Strabismus
(drug therapy, pathology, surgery)
- Suture Techniques
- Tissue Adhesions
(prevention & control)
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