Abstract | UNLABELLED: CONCLUSIONS:
Imipenem and cephaloglycin have essentially the same patterns of toxicity to the mitochondrial metabolism of all metabolic substrates that have been tested. Although cephaloridine has similar effects on dicarboxylic substrates, it is significantly less toxic to the mitochondrial metabolism of pyruvate and the short-chain fatty anions. It is proposed that cephaloridine's zwitterionic charge may restrict its ability to acylate monocarboxylic and other anionic carriers, resulting in less nephrotoxicity than might otherwise result from its uniquely high intracellular concentrations and singular ability among the toxic beta-lactams to produce oxidative injury.
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Authors | B M Tune, C Y Hsu |
Journal | The Journal of pharmacology and experimental therapeutics
(J Pharmacol Exp Ther)
Vol. 274
Issue 1
Pg. 194-9
(Jul 1995)
ISSN: 0022-3565 [Print] United States |
PMID | 7616399
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Bacterial Agents
- Butyrates
- Pentanoic Acids
- Pyruvates
- beta-Lactams
- Butyric Acid
- Pyruvic Acid
- n-pentanoic acid
- Oxygen
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Topics |
- Animals
- Anti-Bacterial Agents
(toxicity)
- Butyrates
(metabolism)
- Butyric Acid
- Female
- Kidney
(drug effects, metabolism)
- Mitochondria
(drug effects, metabolism)
- Oxygen
(metabolism)
- Pentanoic Acids
(metabolism)
- Pyruvates
(metabolism)
- Pyruvic Acid
- Rabbits
- beta-Lactams
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