Serum hydroxyproline and hydroxylysine levels in patients with decompensated cirrhosis.

Abstract

An increase in total (72.67-8.24 mumol/l) and free (14.14-1.97 mumol/l) hydroxyproline and total (7.16-0.72 mumol/l) and free (1.06-0.24 mumol/l) hydroxylysine was found in the serum of 30 patients with decompensated hepatic cirrhosis as compared to the values in 40 healthy subjects (48.70-5.89; 8.41-4.73; 4.34-2.71; 0.77-0.25 mumol/l, respectively). The results were not related to total serum protein concentration. The level of peptide-bound hydroxyproline and peptide-bound hydroxylysine was significantly higher in cirrhotic patients despite the decrease in serum protein content.

• Authors: E J Kucharz
• Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne (Rom J Intern Med) 1994 Oct-Dec Vol. 32 Issue 4 Pg. 271-4 ISSN: 1220-4749 [Print] Germany
• PMID: 7613499 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Hydroxylysine
• Hydroxyproline

Topics

• Adult
• Ascites (blood)
• Chronic Disease
• Female
• Humans
• Hydroxylysine (blood)
• Hydroxyproline (blood)
• Liver Cirrhosis, Alcoholic (blood)
• Male
• Middle Aged