Thermoregulatory activity of sodium nitroprusside and arginine vasopressin.

Abstract

1. Thermal responses to sodium nitroprusside (SNP, 3 mg/kg/hr) and arginine vasopressin (AVP, 3 micrograms/kg) were investigated in normothermic and febrile rabbits (LPS, 1 microgram/kg) at ambient temperature of 20.0 +/- 1.0 degrees C. Furthermore, blood pressure after these drugs was tested on a separate group of animals. 2. I.v. infusion of SNP produced hypothermia and attenuated pyrogen fever. On the other hand, AVP increased body temperature and intensified the febrile response. 3. Both drugs affected in an opposite way blood pressure, i.e. SNP produced falls and AVP increases in this parameter. 4. The relationship between the activity of the vascular and thermoregulatory systems in normothermic or febrile state is discussed.

• Authors: I T Gagało, E E Hać, M T Matuszek, P Rekowski, G Kupryszewski, K Z Korolkiewicz
• Journal: General pharmacology (Gen Pharmacol) Vol. 26 Issue 2 Pg. 393-7 (Mar 1995) ISSN: 0306-3623 [Print] England
• PMID: 7590093 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipopolysaccharides
• Pyrogens
• Arginine Vasopressin
• Nitroprusside

Topics

• Animals
• Arginine Vasopressin (pharmacology)
• Blood Pressure (drug effects)
• Body Temperature Regulation (drug effects)
• Ear, External
• Female
• Lipopolysaccharides (pharmacology)
• Male
• Metabolism (drug effects)
• Nitroprusside (pharmacology)
• Pyrogens
• Rabbits
• Respiration (drug effects)
• Skin Temperature (drug effects)