Abstract | OBJECTIVE: PATIENTS AND DESIGN: In nine patients with idiopathic hypothalamic hypogonadism--mean age 21 +/- 1 (mean +/- SE)--a combined pituitary stimulation (CPS) with 200 micrograms TRH, 100 micrograms GnRH, 100 micrograms CRH and 100 micrograms GRH and an insulin tolerance-test (ITT) with 0.1 U insulin/kg body weight were performed. Both tests were repeated during pulsatile GnRH therapy and thereafter on testosterone replacement. MEASUREMENTS:
Hormone levels were measured by immunometric assays. For statistical analysis the area under the curve (AUC) was used as a measure for hormone response. RESULTS:
Testosterone levels did not differ significantly during GnRH therapy (16.6 +/- 2.1 nmol/L) and testosterone replacement (18.5 +/- 1.7 nmol/L). No significant differences were observed before and during the two treatment modalities for TSH and ACTH. PRL increase was significantly higher during GnRH therapy (AUC: 73580 +/- 8940) compared to the rise before treatment (AUC: 36161 +/- 5853; p < 0.01) and on testosterone replacement (AUC: 49995 +/- 6158; p < 0.01). The GH response to CPS and ITT was higher under testosterone replacement (AUC: 1826 +/- 353 and 1423 +/- 125) compared with the pretreatment situation (AUC: 727 +/- 115; p < 0.05 and 541 +/- 110; p < 0.01) and also more pronounced than under GnRH therapy (AUC: 1148 +/- 180 and 798 +/- 129; p < 0.05). FSH and LH after CPS rose significantly more during GnRH therapy (AUC: 864 +/- 122 and 2215 +/- 219) than before (AUC: 418 +/- 61 and 1424 +/- 277; p < 0.01) and on testosterone treatment (342 +/- 83 and 1153 +/- 323; p < 0.05). CONCLUSION: These results show that GnRH exerts a stimulatory effect on PRL secretion and may modulate GH secretion independently from sex steroids.
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Authors | J Schopohl, J Mojto, M Losa, G Mehltretter, O A Müller, K von Werder |
Journal | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
(Exp Clin Endocrinol Diabetes)
Vol. 103
Issue 3
Pg. 184-90
( 1995)
ISSN: 0947-7349 [Print] Germany |
PMID | 7584521
(Publication Type: Journal Article)
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Chemical References |
- Pituitary Hormones, Anterior
- Gonadotropin-Releasing Hormone
- Testosterone
- testosterone enanthate
- Prolactin
- Luteinizing Hormone
- Follicle Stimulating Hormone
- Growth Hormone-Releasing Hormone
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Topics |
- Adolescent
- Adult
- Follicle Stimulating Hormone
(metabolism)
- Gonadotropin-Releasing Hormone
(therapeutic use)
- Growth Hormone-Releasing Hormone
(therapeutic use)
- Humans
- Hypogonadism
(drug therapy, etiology, metabolism)
- Luteinizing Hormone
(metabolism)
- Male
- Pituitary Hormones, Anterior
(metabolism)
- Prolactin
(metabolism)
- Testosterone
(analogs & derivatives, metabolism, therapeutic use)
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