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1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity.

Abstract
A series of (fluorobenzyl)triazolo[4,5-c]pyridines was synthesized and tested for activity against maximal electroshock-induced seizures in rodents. The most promising compound, 14 (BW 534U87), which is a carbon-nitrogen isoster of a purine anticonvulsant, has a profile in rodents that suggests 14 will be free of emesis and useful in the treatment of seizure disorders for which phenytoin is presently indicated.
AuthorsJ L Kelley, C S Koble, R G Davis, E W McLean, F E Soroko, B R Cooper
JournalJournal of medicinal chemistry (J Med Chem) Vol. 38 Issue 20 Pg. 4131-4 (Sep 29 1995) ISSN: 0022-2623 [Print] United States
PMID7562950 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Triazoles
  • BW 534U87
Topics
  • Animals
  • Anticonvulsants (chemical synthesis, pharmacology)
  • Dogs
  • Male
  • Rats
  • Structure-Activity Relationship
  • Triazoles (chemical synthesis, pharmacology)

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